An unusual follower peptide is required for biosynthesis of the antibiotic lasso peptide triculamin
Triculamin is a potent antibiotic lasso peptide first isolated in 1967. Previous studies have demonstrated that its biosynthesis follows a non-canonical logic unlike any other…
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By Priya Raman · Science Reporter
Oct 26 02:37 ETSource: Nature
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Read at nature.comAn unusual follower peptide is required for biosynthesis of the antibiotic lasso peptide triculamin
Triculamin is a potent antibiotic lasso peptide first isolated in 1967. Previous studies have demonstrated that its biosynthesis follows a non-canonical logic unlike any other lasso peptide. In this study, we investigate the role of the unusual follower peptide and demonstrate that it is essential for biosynthesis. Using structural prediction and targeted mutations of key conserved residues, we hy
