Researchghk-cuwound healingmicroneedlesystematic review

Systematic review finds no powered human trials of microneedle-delivered GHK-Cu

Searches of 1,247 records retained 64 for synthesis, with authors reporting four decades of preclinical work and thin, fragmented human evidence.

By Priya Raman · Science Reporter

Jun 30 20:00 ETSource: Archives of internal medicine research

The wire

01The PRISMA-mapped review of GHK-Cu literature from 2005 to 2026 found not a single registered, adequately powered human randomized trial of microneedle-mediated delivery published in the peer-reviewed literature.
02Clinicians offering GHK-Cu for photoaging, alopecia or post-procedure wound healing are working from in vitro, porcine ex vivo and rodent data, plus small trials of facial cosmetic creams.
03Authors propose indication-stratified trial designs; the paper is a narrative-heavy systematic review in a low-profile journal and does not add new clinical data.

From the source

A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials
Archives of internal medicine research · 2026 Jul · Najafi N, Maatouk H, Vardanyan KG et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42787770/