Friday, September 18, 2026RSS
Peptide.Wire

The daily wire on therapeutic peptides. Regulatory, research, compounding and the incretin race, condensed.

GLP-1tirzepatidedulaglutidesurpass-cvottype 2 diabetes

SURPASS-CVOT exit interviews report benefits from tirzepatide, dulaglutide

Of 74 interviewed participants, 97.3% described improved glycemic control and 28.4% reported nausea as the most common adverse event.

The wire

  1. 01Researchers interviewed 74 of 147 invited SURPASS-CVOT participants (mean age 68.9, 63.5% male) across 10 US sites; 43 had taken tirzepatide, 31 dulaglutide.
  2. 02Patients cited weight reduction (91.9%), reduced appetite (78.4%), and some improvement in joint pain (18.9%) and sleep apnea (8.1%), useful for counseling expectations.
  3. 03Qualitative, self-reported, unblinded and conducted among trial completers, so it cannot compare the two drugs or quantify benefit.

From the source

Exit Interviews Examining Patient Experiences with Tirzepatide and Dulaglutide for Treatment of Type 2 Diabetes in the SURPASS-CVOT Trial

Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026 Sep 17 · Stewart KD, Matza LS, Chinthammit C et al.

Read at pubmed.ncbi.nlm.nih.gov