SELECT analysis finds baseline traits cannot predict semaglutide weight loss
Median peak weight loss was 12.5% after a median 19 months among 7,594 participants treated for at least one year.
MH
By Maren Holt · Senior Reporter, GLP-1
Sep 23 20:00 ETSource: Diabetes care
The wire
- 01In this prespecified SELECT analysis in Diabetes Care, the full predictor model explained under 10% of variability in peak percentage body weight loss; female sex drove 85.3% of that model.
- 02Clinicians cannot tell patients at initiation how much weight they will lose; dose mattered, with median peak loss of 13.3% at 2.4 mg versus 6.0% at 0.24 mg.
- 03The cohort was older, 72% men, with atherosclerotic disease and without diabetes, limiting generalizability to broader obesity populations.
From the source
Read at pubmed.ncbi.nlm.nih.govPredictors of Peak Body Weight Loss With Semaglutide in the SELECT Trial
Diabetes care · 2026 Sep 24 · Lingvay I, Kushner RF, Kaul U et al.
Source URL https://pubmed.ncbi.nlm.nih.gov/42782193/
