Humanin pretreatment limits liver injury in Klebsiella-infected mice

The wire

1. 01Mice given intraperitoneal humanin at 2.5 or 5 mg/kg/day for five days before hvKP challenge showed lower ALT, AST and PCT, reduced NF-kB activation and, at 5 mg/kg, longer survival.
2. 02Humanin is tracked by readers as a mitochondria-derived longevity peptide; this is one of the few datasets linking it to infection-driven inflammation and macrophage signaling.
3. 03The work is a mouse pretreatment model with a 20-patient observational comparison; the authors note humanin's molecular targets remain unknown.

From the source

Humanin Attenuates Inflammatory Liver Injury and NF-κB Activation During Systemic Hypervirulent Klebsiella pneumoniae Infection

Pathogens (Basel, Switzerland) · 2026 Sep 10 · Zhong Y, Haishaer D, Cai W et al.