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Angewandte Chemie reviews macrocyclic peptides with unnatural amino acids

The paper surveys therapeutic development of macrocycles built from non-natural building blocks.

PR
By Priya Raman · Science Reporter
Sep 15 20:00 ETSource: Angewandte Chemie (International ed. in English)

The wire

  1. 01A review in Angewandte Chemie covers macrocyclic peptides containing unnatural amino acids in therapeutic development.
  2. 02Unnatural residues can improve stability and target binding beyond natural peptide limits.
  3. 03The review does not report new clinical candidates or trial outcomes.

From the source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie (International ed. in English) · 2026 Sep 16 · Sharma KK, Sharma K, Sharma A et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42750055/