Vaisala pitches inline refractive index monitoring for peptide synthesis control
The vendor article argues continuous RI readings can mark reaction endpoints in solid-phase peptide synthesis and cut solvent and reagent use.
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By Tom Reyes · Markets Editor
Sep 21 06:54 ETSource: Scientist Live
The wire
- 01Vaisala's Tamara Murusidze describes inline refractive index measurement as a process analytical tool tracking coupling, deprotection, wash-out and endpoint behavior during solid-phase peptide synthesis.
- 02Manufacturing and MSAT teams supplying peptide therapeutics face pressure to reduce solvent consumption and improve real-time process understanding without adding analytical complexity.
- 03The piece is written by a supplier of the instrumentation and cites a single evaluation by de la Torre et al; RI identifies concentration changes, not molecular identity.
From the source
Read at scientistlive.comHow inline refractive index monitoring can improve real-time peptide manufacturing
Peptide therapeutics are becoming increasingly important across modern pharmaceutical pipelines. At the same time, peptide manufacturing remains under strong pressure to improve process efficiency, reduce solvent and reagent consumption, and generate stronger real-time process understanding. Process engineering, manufacturing and MSAT (Manufacturing Science and Technology) teams are facing the cha
