Review maps oral delivery routes for peptide drugs past gut barriers

The wire

1. 01A review in Pharmaceuticals covering literature through May 2026 catalogs barriers to oral peptide bioavailability: enzymatic degradation, low intestinal permeability, mucus entrapment and presystemic metabolism.
2. 02Strategies reviewed include peptide modification, enzyme inhibition, permeation enhancement, mucolytics and advanced carriers, the same toolkit behind current oral peptide formulation work.
3. 03It is a qualitative narrative review with no new data or head-to-head comparison of platforms, so clinical translation timelines remain the authors' expectation rather than a finding.

From the source

Emerging Technologies for Oral Peptide Delivery: From Bioinspired Systems to Smart Device-Assisted Drug Delivery

Pharmaceuticals (Basel, Switzerland) · 2026 Aug 23 · Vasović S, Vasović L, Martić N et al.