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Researchers model brain-derived alpha-synuclein fibrils, mapping peptide recognition

Protein Science paper reports full-length fibril models showing the disordered fuzzy coat governs how peptides bind aggregated alpha-synuclein.

PR
By Priya Raman · Science Reporter
Sep 17 13:00 ETSource: Protein science : a publication of the Protein Society

The wire

  1. 01Pintado-Grima, Bárcenas, Tesei and colleagues built full-length models of brain-derived alpha-synuclein fibrils.
  2. 02Findings suggest the fuzzy coat controls peptide recognition, relevant to designing peptide binders for synucleinopathies.
  3. 03Experimental validation and therapeutic application remain to be demonstrated.

From the source

Full-length brain-derived α-synuclein fibril models reveal fuzzy-coat control of peptide recognition

Protein science : a publication of the Protein Society · 2026 Oct · Pintado-Grima C, Bárcenas O, Tesei G et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42742050/