UC San Diego reports catestatin cuts amyloid, tau in Alzheimer's mice

The wire

1. 01Researchers at UC San Diego and the VA San Diego Healthcare System report in Molecular Therapy that catestatin acted across several neurodegenerative pathways in mouse models, reducing amyloid and tau accumulation.
2. 02Catestatin is an endogenous peptide derived from chromogranin A already implicated in cardiovascular, metabolic and immune regulation, adding a multi-pathway candidate to the neuro-peptide field readers track.
3. 03Findings are in mice only, with no dosing or human data reported; the team says it is still investigating whether catestatin alters neuronal energy metabolism.

From the source

Natural Peptide Counters Multiple Hallmarks of Alzheimer’s

Researchers at UC San Diego have identified catestatin (CST), a naturally occurring peptide fragment, that simultaneously reduces amyloid and tau buildup, quells neuroinflammation, and improves cognitive and motor performance in mouse models of neurodegenerative disease . Unlike single-target therapies, CST acts across several interconnected pathological pathways, pointing toward a versatile pepti