Tuesday, September 22, 2026RSS
Peptide.Wire

The daily wire on therapeutic peptides. Regulatory, research, compounding and the incretin race, condensed.

Researchmots-cmitochondriaischemia-reperfusionnrf2

MOTS-c links ischemic preconditioning to lung reperfusion protection, study finds

Researchers report the mitochondrial peptide acts through NRF2-dependent mitochondrial biogenesis in a model of lung ischemia-reperfusion injury.

PR
By Priya Raman · Science Reporter
Sep 20 20:00 ETSource: Chinese medical journal

The wire

  1. 01A Chinese Medical Journal paper reports that MOTS-c mediates remote ischemic preconditioning's protective effect against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis.
  2. 02MOTS-c is closely tracked by readers following mitochondrial and longevity peptides, and this adds an organ-protection mechanism to its profile.
  3. 03Preclinical mechanistic work only; no human dosing, safety or outcome data, and the abstract details are limited.

From the source

MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis

Chinese medical journal · 2026 Sep 21 · Sun J, Xu B, Wang D et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42767971/