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Peptide.Wire

The daily wire on therapeutic peptides. Regulatory, research, compounding and the incretin race, condensed.

Researchphage displaypeptide drug discoverymacrocyclic peptides

Review maps phage display as engine of peptide drug discovery

Authors in Pharmaceuticals argue cyclization, non-canonical and D-amino acids and stapling are what turn biopanning hits into usable drugs.

PR
By Priya Raman · Science Reporter
Aug 10 20:00 ETSource: Pharmaceuticals (Basel, Switzerland)

The wire

  1. 01A narrative review describes how phage display libraries and biopanning identify high-affinity peptide ligands, several of which have reached approval.
  2. 02Explains why many peptide leads stall on pharmacological properties, relevant to anyone tracking the macrocyclic and engineered-peptide pipeline.
  3. 03It is a review rather than new data, and offers no head-to-head comparison with other display or synthesis platforms.

From the source

Phage Display as a Promising Platform for Peptide Drug Discovery

Pharmaceuticals (Basel, Switzerland) · 2026 Aug 11 · Bakhshinejad B, Kajer A et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42653761/