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Humanin/CRP ratio predicts cardiac events in Chinese heart failure cohort

Retrospective study of 154 patients found rehabilitation improved walk distance, but the 15% absolute reduction in adverse events was not statistically significant.

PR
By Priya Raman · Science Reporter
Sep 17 22:01 ETSource: Zhonghua xin xue guan bing za zhi

The wire

  1. 01Non-randomized retrospective cohort at Nanjing Medical University's Third Affiliated Hospital enrolled 154 patients with acute exacerbation of chronic heart failure; serum Humanin/CRP ratio was tested as a prognostic marker by Cox regression.
  2. 02Humanin is a mitochondria-derived peptide readers track for longevity and mitochondrial indications; here it appears as a prognostic biomarker rather than a therapy.
  3. 03Rehabilitation group had 34% major adverse cardiovascular events versus 49% in controls over six months, a difference the authors report as not statistically significant; design was retrospective and single-center.

From the source

[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure]

Zhonghua xin xue guan bing za zhi · 2026 Sep 24 · Li CY, Zhang NN, Yang YL et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42736132/