Calmodulin tagging boosts recombinant LL-37 production, researchers report

The wire

1. 01Study shows calmodulin-tagging accommodates LL-37's hydrophobic regions, preventing aggregation and aiding proteolytic release.
2. 02Addresses a manufacturing bottleneck for producing antimicrobial peptides recombinantly.
3. 03Scale-up yields and commercial feasibility are not addressed.

From the source

Calmodulin-tagging prevents aggregation and facilitates the proteolytic release of the recombinant human cathelicidin LL-37 by accommodating its hydrophobic regions

International journal of biological macromolecules · 2026 Sep 11 · Shibagaki M, Chrisnanto JO, Tefera DA et al.