Thursday, September 17, 2026RSS
Peptide.Wire

The daily wire on therapeutic peptides. Regulatory, research, compounding and the incretin race, condensed.

Researchliraglutidesemaglutideglucagonformulationpolysorbate

Polysorbate 80 worsens liraglutide aggregation under agitation, formulation study finds

Semaglutide's more stable oligomers resisted surfactant effects, while glucagon fibrillated regardless of which surfactant was added.

PR
By Priya Raman · Science Reporter
Sep 1 20:00 ETSource: Journal of pharmaceutical sciences

The wire

  1. 01Journal of Pharmaceutical Sciences researchers tested polysorbate 80, polysorbate 20 and poloxamer 188 on liraglutide, semaglutide and glucagon under agitation stress using SEC, CD and NMR.
  2. 02PS80 bound liraglutide specifically and drove the fastest aggregation; PS20 was less disruptive, a caution for anyone formulating or repackaging peptide parenterals.
  3. 03Findings are molecule-dependent bench data under forced agitation stress, not shelf-life or clinical stability results for marketed products.

From the source

Impact of surfactants on the stability of therapeutic peptides under interfacial stress

Journal of pharmaceutical sciences · 2026 Sep 2 · Hamada N, Wuelfing WP, Su Y et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42679928/