Ferritin-fused LL-37 outperforms free peptide in murine sepsis model

The wire

1. 01Researchers fused LL-37 to the C-terminus of ferritin light chain; the construct retained antimicrobial activity and showed better antibacterial and anti-inflammatory effect than free LL-37 in mice with sepsis.
2. 02LL-37's poor stability and rapid degradation are the main barriers readers following the peptide have tracked; a carrier fusion is one route around them.
3. 03Safety testing reported no significant hemolysis, immunogenicity or tissue toxicity, but this is a mouse model with no human data and no clinical program described.

From the source

Targeted delivery of antimicrobial peptide LL-37 via ferritin fusion improves antibacterial and anti-inflammatory outcomes in a murine sepsis model

International journal of biological macromolecules · 2026 Aug 31 · Pan W, Tian C, Ding Y et al.