Researchsemaglutideprader-willi syndromehyperphagiaobesity

Semaglutide stabilises weight, cuts hyperphagia in 12 Prader-Willi adults

In the UK retrospective cohort, hyperphagia questionnaire scores fell 7.3 points while weight did not significantly decline over a median 17 months.

By Priya Raman · Science Reporter

Sep 2 20:00 ETSource: Frontiers in endocrinology

The wire

01Twelve adults with Prader-Willi syndrome (mean BMI 46.6, 75% with type 2 diabetes) on median 2.4 mg weekly semaglutide showed -3.1% weight change versus +5.7% gain beforehand (P=0.037).
02Hyperphagia scores dropped 7.3 points (P=0.003) and HbA1c improved in the six with elevated baseline; mild gastrointestinal effects in 25% caused no discontinuations.
03The authors call it a small open-label observational cohort and say larger placebo-controlled trials are needed, including adolescents and patients without type 2 diabetes.

From the source

Efficacy and safety of semaglutide for obesity and hyperphagia in adults with Prader-Willi syndrome
Frontiers in endocrinology · 2026 · Ahmed S, Bridges N, Goldstone AP et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42755517/