Review finds sex, diabetes status shape semaglutide weight loss
Women lost about 6% more weight than men, while type 2 diabetes blunted response and the 7.2 mg dose beat 2.4 mg by roughly 3%.
MH
By Maren Holt · Senior Reporter, GLP-1
Sep 16 20:00 ETSource: Frontiers in endocrinology
The wire
- 01A mini review in Frontiers in Endocrinology summarizes predictors of semaglutide-driven weight loss: type 2 diabetes lowers response, females lose a mean 6% more than males, and 7.2 mg outperforms 2.4 mg by about 3%.
- 02Prescribers counselling patients on expected outcomes can anchor on these factors; age and baseline BMI showed no clear association, and lifestyle-modification type did not drive variability.
- 03Authors say genetic predictors are limited to a modest GLP1 receptor variant effect and 'hungry gut' phenotype data are preliminary; validated predictive models do not yet exist.
From the source
Read at pubmed.ncbi.nlm.nih.govPredictors of treatment response to semaglutide for weight management
Frontiers in endocrinology · 2026 · Tzoulis P et al.
Source URL https://pubmed.ncbi.nlm.nih.gov/42824923/
