Neutron scattering shows octreotide reshapes sodium caprate micelles

The wire

1. 01SANS with contrast variation examined 100 mM and 300 mM sodium caprate in fasted- and fed-state simulated intestinal fluid; octreotide produced bilayer discs at pH 6.5 and rod-like micelles at pH 8.5.
2. 02Caprate is a widely used permeation enhancer in oral peptide formulations, so excipient-peptide structure helps explain variable absorption.
3. 03Findings are in simulated fluids with coarse-grained simulations, not in vivo; translation to human oral bioavailability is untested.

From the source

Self-assembly of sodium caprate in simulated intestinal fluids and with a therapeutic peptide: A small-angle neutron scattering study

International journal of pharmaceutics: X · 2026 Dec · Akter S, Bergström LM, Hansson P et al.