Follicular kisspeptin-54 and VEGF rise in PCOS and hyperstimulation

The wire

1. 01Retrospective cross-sectional study measured follicular fluid Kisspeptin-1, Kisspeptin-54 and VEGF by ELISA in 30 normoresponders, 30 women with PCOS and 30 who developed OHSS; all differed significantly (p<0.001).
2. 02Kisspeptin-54 (OR 1.031) and VEGF (OR 1.008) remained associated with OHSS alongside AFC, AMH and trigger-day estradiol, adding to the case that kisspeptin signalling reflects ovarian hyperresponsiveness.
3. 03Design is retrospective with 30 patients per arm and measures kisspeptin as a marker, not a therapy; the authors frame the peptides as complementary indicators pending prospective work.

From the source

Follicular kisspeptin-VEGF axis in polycystic ovary syndrome and ovarian hyperstimulation syndrome

Journal of assisted reproduction and genetics · 2026 Aug 28 · Korkmaz O, Karabulut S, Macit P et al.