S14G-humanin cuts oxidative stress in rat kidney ischaemia-reperfusion model

The wire

1. 01In 48 Sprague-Dawley rats undergoing 45 minutes of renal artery ligation and 24 hours of reperfusion, S14G-humanin 2 mg/kg i.v. restored glutathione and superoxide dismutase, cut myeloperoxidase and malondialdehyde, and reduced apoptotic cells.
2. 02Humanin analogues are tracked by readers following mitochondrial and longevity peptides; this adds a mechanistic signal via STAT3 and ERK1/2 phosphorylation.
3. 03Functional renal markers, blood urea nitrogen and serum creatinine, were unchanged by treatment, and the work is a single acute rat model with no human data.

From the source

S14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats

Experimental physiology · 2026 Aug 31 · Abueid L, Torun AF, Golal E et al.