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Mayo Clinic recruits for fasting protocol trial in GLP-1 users before endoscopy

The study tests whether extending pre-procedure fasting lowers gastric residual volume, the proxy for aspiration risk in patients on GLP-1 receptor agonists.

By Priya Raman · Science Reporter

Oct 5 08:00 ETSource: ClinicalTrials.gov

The wire

01Mayo Clinic is recruiting for NCT07006142, a non-randomized study started August 1, 2025, measuring gastric residual volume at upper endoscopy under a modified fasting protocol in patients prescribed GLP-1 receptor agonists.
02Pre-procedure fasting guidance for GLP-1 patients remains contested between anesthesiology and gastroenterology groups, and endoscopy schedulers and prescribers still lack trial data to justify holding or extending fasts.
03The trial is listed as recruiting with no results posted; gastric residual volume is a surrogate for aspiration, not a measure of aspiration events themselves.

From the source

Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists
NCT07006142 · NA · RECRUITING · Sponsor: Mayo Clinic · Conditions: Upper Endoscopy, GLP1-R-related Disease.

Read at clinicaltrials.gov

Source URL https://clinicaltrials.gov/study/NCT07006142