Indirect comparison puts tirzepatide 15 mg 6.5 kg ahead of semaglutide

The wire

1. 01Unadjusted indirect treatment comparison found tirzepatide 10 and 15 mg beat semaglutide 2.4 mg on weight change (-5.10 kg and -6.50 kg), BMI, waist circumference, HbA1c and fasting glucose.
2. 02In the body-composition subset, tirzepatide 15 mg cut percentage fat mass 3.50% and raised percentage lean mass 3.40% versus semaglutide, a distinction clinicians are increasingly asked about.
3. 03This is a cross-trial indirect comparison at Week 68 and Week 72 endpoints, not a head-to-head randomised trial; adjustments covered only sex and ethnicity.

From the source

Indirect comparative efficacy and safety of tirzepatide vs semaglutide for the treatment of obesity or overweight in patients without type 2 diabetes

International journal of obesity (2005) · 2026 Sep 28 · Ciudin A, Johansson E, Zimner-Rapuch S et al.