Tirzepatide raised lithium levels slightly in 23 bipolar patients, single-centre review finds

The wire

1. 01In the retrospective cohort of 23 lithium-treated adults, lithium rose by 0.08 ± 0.17 mmol/L at 12 weeks (p = 0.030) while creatinine and eGFR changes were not significant; 20 completers lost 17.7 ± 6.0% of body weight at 12 months.
2. 02Authors conclude co-prescription warrants structured monitoring and sick-day education, a practical point for prescribers starting incretins in psychiatric patients.
3. 03Single centre, 23 patients, retrospective records; no KDIGO-criteria acute kidney injury could be confirmed, and the authors caution creatinine-based eGFR gains during major weight loss do not establish renal benefit.

From the source

Tirzepatide Initiation in Lithium-Treated Bipolar Disorder: Renal Biomarker Trajectories and Lithium Safety Signals Over 12 Months in a Real-World Cohort

Human psychopharmacology · 2026 Nov · Rescalli MB, Fagiolini A, Carmellini P et al.