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Researchpa-hyb1pseudomonas aeruginosaantimicrobial resistancepeptide design

Designed peptide PA-Hyb1 targets MexB efflux pump in Pseudomonas

Computational study characterizes a hybrid peptide inhibitor aimed at a key antibiotic-resistance efflux transporter.

PR
By Priya Raman · Science Reporter
Sep 11 20:00 ETSource: Journal of molecular modeling

The wire

  1. 01Authors report rational hybrid design and modeling of PA-Hyb1 against the MexB efflux pump in Pseudomonas aeruginosa.
  2. 02Efflux pump inhibition is a route to restoring antibiotic activity in resistant infections.
  3. 03Findings are in silico only; laboratory validation has not been reported.

From the source

Rational hybrid design and computational characterization of PA-Hyb1: a novel peptide inhibitor targeting the MexB efflux pump in Pseudomonas aeruginosa

Journal of molecular modeling · 2026 Sep 12 · Abdel-Aziem SH et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42730777/