Thursday, September 17, 2026RSS
Peptide.Wire

The daily wire on therapeutic peptides. Regulatory, research, compounding and the incretin race, condensed.

Researchirf1osteoporosisampkmtorbmscs

IRF1 curbs bone marrow fat via AMPK-mTOR axis in osteoporosis study

FASEB Journal paper reports interferon regulatory factor 1 blocks adipogenic differentiation of bone marrow stromal cells and induces autophagy.

PR
By Priya Raman · Science Reporter
Sep 17 19:00 ETSource: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

The wire

  1. 01Researchers report IRF1 inhibits adipogenic differentiation of BMSCs through AMPK-mTOR signaling and triggers autophagy.
  2. 02Findings point to a molecular target for osteoporosis-related bone marrow adiposity.
  3. 03Preclinical work; translation to human therapy remains unaddressed in the report.

From the source

Interferon Regulatory Factor 1 Inhibits the Adipogenic Differentiation of BMSCs via the AMPK-mTOR Signaling Axis and Induces Their Autophagy to Alleviate Osteoporosis-Related Bone Marrow Adiposity

FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 Sep 30 · Hu M, Wei E, Wu L et al.

Read at pubmed.ncbi.nlm.nih.gov
Source URL https://pubmed.ncbi.nlm.nih.gov/42753138/