Low deep-breathing heart rate variability flags early oral semaglutide dropout

The wire

1. 01A multicenter retrospective study in the Journal of Diabetes Investigation screened 203 patients starting oral semaglutide and analyzed 61; lower CVR-R during deep breathing was independently associated with discontinuation for nausea or vomiting (adjusted OR 0.191, AUC 0.832).
2. 02A cutoff of 2.55% separated six-month persistence of 43.3% versus 87.1%, suggesting a bedside autonomic test could help flag patients likely to abandon oral semaglutide at initiation.
3. 03The analysis is retrospective, single-country and small after exclusions, the cutoff was internally derived, and the difference versus resting CVR-R did not reach significance (DeLong P=0.085).

From the source

Parasympathetic dysfunction assessed by deep-breathing CVR-R is associated with early discontinuation of oral semaglutide in type 2 diabetes: A multicenter retrospective study

Journal of diabetes investigation · 2026 Oct 24 · Ogiso K, Deguchi T, Kawade S et al.