GLP-1glp-1schizophreniahba1creal-world evidence

Danish registers show GLP-1 cuts HbA1c and lipids in schizophrenia

Among 3,042 patients, triglycerides fell 14.8% and HbA1c 11.4% after GLP-1 initiation for diabetes, with smaller drops when started for overweight.

By Maren Holt · Senior Reporter, GLP-1

Oct 22 20:00 ETSource: The British journal of psychiatry : the journal of mental science

The wire

01Interrupted time-series analysis of Danish nationwide registers covering 1996 to 2023 found statistically significant reductions in HbA1c, LDL and triglycerides after GLP-1 receptor agonist initiation in 3,042 people with schizophrenia.
02The findings suggest trial-level metabolic benefits extend to routine care in a population with high antipsychotic-related metabolic burden.
03The design is observational with no control group, so secular trends, concurrent medication changes and adherence cannot be ruled out as contributors.

From the source

Metabolic biomarker levels before and after initiation of GLP-1 receptor agonist treatment among individuals with schizophrenia: interrupted time-series analysis
The British journal of psychiatry : the journal of mental science · 2026 Oct 23 · Mikkelsen NB, Ørberg A, Østergaard SD et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42922018/