Semaglutide cuts BMI-SDS in two children under six with severe obesity

The wire

1. 01In Hormone Research in Paediatrics, a 4.5-year-old girl titrated to 1.5 mg/week saw BMI-SDS fall from +5.5 to +4.1 over 18 months, and a 3.3-year-old boy titrated to 2.0 mg/week fell from +5.7 to +4.4 over 21 months.
2. 02Clinicians facing severe early-onset and monogenic obesity have few pharmacological options below age six, and these reports describe tolerability and preserved linear growth.
3. 03This is a two-patient case report with no control group; the authors say larger studies are needed before the approach can be generalized.

From the source

SEMAGLUTIDE TREATMENT IN TWO VERY YOUNG CHILDREN WITH SEVERE EARLY-ONSET OBESITY

Hormone research in paediatrics · 2026 Oct 23 · Canbaz AT, Kahveci A, Kurt I et al.