Mouse study finds SCN neuromedin S neurons silence preoptic kisspeptin firing

The wire

1. 01Using tract-tracing, optogenetics and electrophysiology in female mice, researchers report a subset of suprachiasmatic nucleus neuromedin S neurons projects monosynaptically to RP3V kisspeptin neurons and inhibits their firing.
2. 02Kisspeptin signaling underpins the LH surge and is a peptide target readers track in reproductive and fertility work; the finding adds circadian-clock inhibition to that circuit.
3. 03Exogenous neuromedin S itself had only modest effects, and the work is in female mice; implications for LH surge timing are discussed but not demonstrated.

From the source

Monosynaptic GABAergic projections from a subset of suprachiasmatic nucleus neuromedin S neurons suppress preoptic area kisspeptin neuron firing in female mice

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026 Sep 29 · Abdulmajeed WI, Neuman PN, Jamieson BB et al.