Kisspeptin-10 improves sperm motility in obese rats, study reports
Forty Sprague Dawley rats on a 60% fat diet received 50 nmol/kg intraperitoneal kisspeptin-10 for four weeks after 12 weeks of diet-induced obesity.
PR
By Priya Raman · Science Reporter
Sep 27 20:00 ETSource: Reproductive sciences (Thousand Oaks, Calif.)
The wire
- 01Treated obese rats showed lower malondialdehyde, higher glutathione, improved sperm motility and concentration, less DNA damage, and raised PINK1, PHB2 and Beclin-1 expression.
- 02Kisspeptin is tracked by readers on the sexual and reproductive health beat; the paper frames it as acting through redox balance and mitochondrial quality control.
- 03Animal study with four groups of ten rats; mitochondrial membrane potential recovery was non-significant and Parkin, LC3-II and apoptosis proteins were unchanged.
From the source
Read at pubmed.ncbi.nlm.nih.govKisspeptin-10 Alleviates Obesity-induced Testicular Oxidative Stress and Mitochondrial Dysfunction via Modulation of Mitophagy and Autophagy Signaling
Reproductive sciences (Thousand Oaks, Calif.) · 2026 Sep 28 · Arkalı G, Çay M, Güler Ekmen E et al.
Source URL https://pubmed.ncbi.nlm.nih.gov/42806235/
