GLP-1semaglutidetirzepatidelean massaesthetic surgery

Narrative review ties GLP-1 weight loss to 25-30% lean mass depletion

Authors say direct aesthetic surgery outcome data are limited to two case reports and one small cohort, so surgical implications remain inferential.

By Maren Holt · Senior Reporter, GLP-1

Sep 28 20:00 ETSource: Aesthetic surgery journal. Open forum

The wire

01A narrative review in Aesthetic Surgery Journal Open Forum searched PubMed, Embase and Web of Science to March 2026 and found lean soft tissue loss comprising about 25% to 30% of total weight lost across GLP-1 receptor agonist trials.
02Authors argue surgeons should assess body composition rather than weight before facelift, abdominoplasty or fat grafting, flagging patients with rapid loss, low protein intake and no resistance training.
03Evidence is Level 5; the review does not support changing surgical technique for GLP-1 patients as a class, and cessation timing before fat grafting remains unstudied.

From the source

Beyond Skin Laxity: GLP-1 Receptor Agonist-Induced Lean Mass Depletion and Surgical Tissue Quality in Aesthetic Surgery: A Narrative Review
Aesthetic surgery journal. Open forum · 2026 · Cuggy C, O'Broin E et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42820120/