Tirzepatide blunts nicotine reward and accumbal dopamine in male mice

The wire

1. 01In male mice, tirzepatide dose-dependently attenuated nicotine-induced locomotor stimulation, reduced conditioned place preference and lowered nicotine-induced dopamine release in the nucleus accumbens.
2. 02Adds incretin agonists to the list of candidates being explored for nicotine dependence, where relapse and post-cessation weight gain remain barriers.
3. 03Animal study in male mice only, with no human data on smoking cessation; effects on GABA and other transmitters were region-specific and mechanistically unresolved.

From the source

The dual incretin agonist tirzepatide blunts nicotine-induced behaviours and neurochemistry in male mice

British journal of pharmacology · 2026 Sep 28 · Edvardsson CE, Emous TA, Witley S et al.