UC San Diego reports catestatin cuts tau and amyloid in mouse models

The wire

1. 01UC San Diego School of Medicine researchers report that catestatin reduced accumulation of tau and amyloid, dampened neuroinflammation, and improved cognitive and motor performance in mouse models of neurodegeneration.
2. 02Senior author Sushil Mahata frames catestatin as acting across several disease pathways at once, an argument for peptide-based approaches in Alzheimer's rather than single-target drugs.
3. 03Findings are preclinical only; the team is still investigating whether catestatin alters brain energy metabolism, and no human dosing, route or safety data exist.

From the source

Naturally Occurring Peptide May Offer New Approach to Neurodegeneration

UC San Diego researchers identify a potential therapeutic strategy that reduces toxic protein accumulation, dampens neuroinflammation and improves brain function in preclinical models