Oral semaglutide cuts HbA1c 0.8% over 24 months in Italian clinic cohort

The wire

1. 01Retrospective study of 232 adults with type 2 diabetes starting oral semaglutide at one Italian clinic found -0.8% HbA1c and -5.7 kg at 24 months, with 44.0% meeting a combined HbA1c and weight endpoint.
2. 02Renal measures stayed stable, total and LDL cholesterol fell, and non-breakfast dosing was independently associated with lower HbA1c after adjustment for BMI, age and sex.
3. 03Single-centre retrospective design with no control arm limits inference; the authors report no safety concerns emerged but discontinuation predictors were modelled rather than randomised.

From the source

Oral Semaglutide in Routine Clinical Practice: 24-Month Real-World Effectiveness, Persistence and Safety in Adults With Type 2 Diabetes

Diabetes, obesity & metabolism · 2026 Sep 21 · Baldassarre MPA, Di Dalmazi G, Carrieri F et al.