GLP-1semaglutidetirzepatidemale fertilitytestosterone

Review finds no powered fertility trials of GLP-1 drugs in men

Authors say semaglutide and liraglutide studies show testosterone gains in metabolically impaired men but cannot separate drug effect from weight loss.

By Maren Holt · Senior Reporter, GLP-1

Sep 19 20:00 ETSource: Journal of clinical medicine

The wire

01The Journal of Clinical Medicine narrative review found no adequately powered prospective GLP-1 study prespecifying sperm DNA fragmentation, conception, clinical pregnancy or live birth, and no controlled tirzepatide study of semen or fertility outcomes.
02Clinicians counseling men of reproductive age on obesity or type 2 diabetes therapy get a structured framework separating endocrine, semen, sexual-function and clinical fertility endpoints.
03The authors state these drugs should be used for metabolic indications, not male infertility, and that their proposed framework is author-developed and non-validated.

From the source

GLP-1 Receptor Agonists and Tirzepatide in Men Seeking Fertility: A Structured Narrative Review and Proposed Clinical Framework
Journal of clinical medicine · 2026 Sep 20 · Kaltsas A, Gkioxaris V, Giannakas T et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42796084/