Semaglutide shifts rat gut microbiome beyond effects of reduced food intake
Pair-fed controls show some microbial changes are independent of hypophagia, with sex-specific links between host metabolic measures and community composition.
PR
By Priya Raman · Science Reporter
Sep 30 20:00 ETSource: Comprehensive physiology
The wire
- 01Diet-induced obese rats got four weeks of semaglutide; 16S rRNA sequencing showed altered richness and evenness, with Clostridiaceae enriched in treated animals and Bacteroidota taxa in controls.
- 02A pair-fed comparison group indicates GLP-1 receptor agonists act on the gut microbiome through both intake-dependent brain-to-gut and intake-independent pathways, relevant to clinicians tracking GI effects.
- 03The authors note the shifts are not necessarily health-positive; this is a rodent study with 16S-level resolution and no clinical outcomes.
From the source
Read at pubmed.ncbi.nlm.nih.govSemaglutide Remodels the Gut Microbiome Beyond Its Appetite-Suppressing Action: Sex-Specific Gut-Brain Axis Implications
Comprehensive physiology · 2026 Oct · Byun S, Sotzen MR, Bento MT et al.
Source URL https://pubmed.ncbi.nlm.nih.gov/42923050/
