Researchhumaninapoptosismitochondriajournal of biological chemistry

Humanin variants curb BAX- and tBID-driven membrane leakage in JBC study

The single cysteine C8 was critical for fibril formation with all forms of BID, while leucine substitutions altered fibril morphology and blocked fibrils with truncated BID.

By Priya Raman · Science Reporter

Oct 22 20:00 ETSource: The Journal of biological chemistry

The wire

01In vitro work in the Journal of Biological Chemistry found humanin fibrils reduced BAX- and tBID-mediated vesicle permeabilization, with inhibition strongly dependent on the order of sample addition.
02Humanin is tracked by longevity-peptide readers, and the paper maps residue-level determinants (C8, L9, L10, L12) behind its reported cytoprotective, anti-apoptotic behavior.
03This is biochemical and electron-microscopy work on isolated proteins, vesicles and mitochondria, with no cellular efficacy or dosing implications.

From the source

Humanin variants differentially regulate BID fibrilization and suppress BAX- and BID-dependent membrane permeabilization
The Journal of biological chemistry · 2026 Oct 23 · Puja R, Morris DL, Wang ZH et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42918500/