Researchglp-1 receptor agoniststotal knee arthroplastyvenous thromboembolismtrinetx

Pre-surgery GLP-1 use tied to lower MI and DVT after knee replacement

In 11,765 matched pairs from TriNetX, postoperative myocardial infarction risk was roughly halved, while pulmonary embolism rates did not differ significantly.

By Priya Raman · Science Reporter

Oct 14 20:00 ETSource: The journal of knee surgery

The wire

01Retrospective TriNetX cohort of primary total knee arthroplasty patients, 1:1 propensity matched to 11,765 per arm, found lower postoperative myocardial infarction (RR 0.528), DVT (RR 0.718) and VTE (RR 0.772) with a GLP-1 prescription in the year before surgery.
02Surgeons and perioperative teams weighing GLP-1 continuation around arthroplasty now have large-cohort signals pointing toward thrombotic benefit rather than harm.
03Pulmonary embolism showed no significant difference (RR 0.847, CI 0.580-1.238), and the design is retrospective claims-style data covering 2006 to 2025, so residual confounding and indication bias remain.

From the source

GLP-1 Receptor Agonist Use Before Total Knee Arthroplasty is Associated With Lower Postoperative MI, DVT, and VTE Rates
The journal of knee surgery · 2026 Oct 15 · Yavari B, Soltankhah A, Eghrari N et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42880346/