Oral exenatide microparticle holds glucose control eight days in diabetic mice

The wire

1. 01Exenatide-chitosan oligosaccharide loaded into porous calcium carbonate/sodium alginate microparticles produced hypoglycemic effects lasting up to eight days after a single oral dose in db/db mice following long-term administration.
2. 02An oral long-acting incretin platform would change delivery economics for a class currently dependent on injections and high-dose oral formulations.
3. 03This is a rodent study with no human data; durability, immune effects of macrophage polarization and manufacturability of the carrier remain untested in people.

From the source

Intestinal Macrophage-Mediated Exosomal Repackaging Establishes Bioactive Reservoirs for Long-Acting Oral Peptide Therapy

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