GLP-1glp-1 receptor agonistsacute kidney injurychronic kidney diseasetype 2 diabetes

GLP-1 users show lower contrast-associated AKI rate in matched CT cohort

TriNetX analysis of diabetes patients with chronic kidney disease found a 0.7 to 1.5 percentage point absolute difference after contrast imaging.

By Maren Holt · Senior Reporter, GLP-1

Oct 15 20:00 ETSource: Acta diabetologica

The wire

01Retrospective TriNetX study of imaging from 2020 to 2025 matched 6,995 CE-CT pairs and 3,285 CTA pairs; AKI within three days occurred in 3.8% of GLP-1 users versus 4.5% after CE-CT.
02For CTA the rate was 4.5% versus 6.1%, odds ratio 0.74, a signal clinicians may weigh when scheduling contrast imaging in diabetic patients with chronic kidney disease.
03Authors note HbA1c remained imbalanced after matching, eGFR-stratified results were inconsistent, and prospective studies using creatinine-based outcomes are needed.

From the source

GLP-1 receptor agonist use and contrast-associated acute kidney injury after contrast-enhanced CT and CT angiography in adults with type 2 diabetes and chronic kidney disease: a propensity score-matched cohort study
Acta diabetologica · 2026 Oct 16 · Chang Y, Chi KY, Lin HM et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42886239/