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Systematic review finds only three human BPC-157 studies totaling 30 patients

All three were judged poor methodological quality, and the authors rate overall certainty of evidence as very low, advising against clinical use outside regulated trials.

By Priya Raman · Science Reporter

Oct 7 20:00 ETSource: Acta orthopaedica Belgica

The wire

01A PRISMA-compliant review in Acta Orthopaedica Belgica searched databases to 1 June 2026 and found three human BPC-157 studies, n=30: intra-articular injections for knee pain (n=16), intravesical for interstitial cystitis (n=12), and intravenous safety (n=2).
02All studies reported symptom improvement in most participants with no treatment-related adverse events, but the authors conclude BPC-157 should not be used clinically outside ethically approved, high-quality trials.
03GRADE certainty was very low due to serious risk of bias, indirectness and imprecision; none of the included studies had a control group.

From the source

Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety
Acta orthopaedica Belgica · 2026 Oct 8 · Poolton JT, Minett J, Kazmi A et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42885452/