GLP-1semaglutidetirzepatideglp-1 receptor agonistssystematic review

Systematic review finds thin evidence on facial changes during GLP-1 weight loss

Only four uncontrolled observational studies with 98 treated participants met eligibility, and none had comparator groups.

By Maren Holt · Senior Reporter, GLP-1

Oct 11 20:00 ETSource: Aesthetic plastic surgery

The wire

01The Aesthetic Plastic Surgery review, registered in PROSPERO and searching databases through June 5, 2026, identified four uncontrolled studies of injectable biostimulators and fillers, bipolar radiofrequency and a topical formulation.
02Clinicians fielding questions about facial volume loss during GLP-1 receptor agonist treatment now have a synthesis showing no validated treatment algorithm exists.
03Authors call the proposed framework hypothesis-generating; heterogeneous populations and absent controls precluded conclusions on effectiveness, and comparative studies are needed.

From the source

Beyond Weight Loss: Facial Remodeling Associated with GLP-1 Receptor Agonists-A Systematic Review and Therapeutic Framework
Aesthetic plastic surgery · 2026 Oct 12 · Maglitto F, Salzano G, Trotta S et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42864543/