Case report ties tirzepatide injections to panic attacks in two women

The wire

1. 01Clinicians writing in Frontiers in Drug Safety and Regulation describe two female patients taking tirzepatide for weight loss who had panic attacks in close temporal proximity to injections, with no clear medical aetiology identified.
2. 02Prescribers screening patients with depressive or anxiety histories now have a documented signal, even as broader safety data for GLP-1 receptor agonists indicate low risk of adverse psychiatric events.
3. 03This is a two-patient case report, not a controlled study; the authors offer delayed gastric emptying, GABAergic deficits, solitary tract nucleus activation and HPA-axis activation only as possible mechanisms.

From the source

Case Report: Panic attacks after tirzepatide injection in two female patients with recurrent depressive disorder

Frontiers in drug safety and regulation · 2026 · Palm U, Backmund M, Himmerich H et al.