Mouse study maps kisspeptin control of GnRH neuron firing across hormone states

The wire

1. 01In acute mouse brain slices, photostimulation of AVPV kisspeptin neurons produced sustained, frequency-dependent increases in GnRH neuron firing; responses were similar in diestrus and proestrus but blunted one week post-ovariectomy.
2. 02Kisspeptin is tracked on the sexual-health peptide beat, and the work details how ovarian steroids maintain the kisspeptin-GnRH circuit that drives the preovulatory surge.
3. 03Monosynaptic connectivity was infrequent and consistently GABAergic; this is a slice electrophysiology study in mice and does not speak directly to kisspeptin dosing in humans.

From the source

Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice

Journal of neuroendocrinology · 2026 Oct · Starrett JR, Chen X, Krasner D et al.