Researchmots-covarian agingmitochondriafertility

MOTS-c boosts bioenergetics in aged human granulosa cells and mouse oocytes

Treated oocytes from aged mice showed improved maturation but did not reach levels seen in young animals, the authors report.

By Priya Raman · Science Reporter

Oct 18 20:00 ETSource: Reproduction & fertility

The wire

01In laboratory work with aged human granulosa cells and oocytes from aged mice, the mitochondrial-derived peptide MOTS-c increased energy production and helped maintain cell structure.
02MOTS-c is tracked closely by longevity-peptide users, and this adds a reproductive-aging mechanism to the existing metabolic literature.
03The work is cell and animal only; it did not test fertilization, embryo development or live birth, and no human fertility conclusions can be drawn.

From the source

The Mitochondrial-Derived Peptide MOTS-c Improves Bioenergetics in Aging-Associated Granulosa Cells and Oocytes
Reproduction & fertility · 2026 Oct 19 · Tsui KH, Cheng SH, Lin LT et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42895211/