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Lamb study links undernutrition to more AgRP input onto kisspeptin neurons

Feed-restricted lambs showed lower Kiss1 expression in MC3R-expressing arcuate cells, pointing to a melanocortin route from energy status to the reproductive axis.

By Priya Raman · Science Reporter

Oct 16 20:00 ETSource: The Journal of reproduction and development

The wire

01Using arcuate tissue from weight-maintained (n=6/sex) and feed-restricted (n=8/sex) lambs, researchers found significantly more AgRP close-contacts onto kisspeptin neurons in restricted animals.
02Kisspeptin signaling underpins gonadorelin/GnRH-axis work, so mechanistic data on how energy deficit suppresses it is relevant to fertility and metabolic peptide research.
03This is a sheep histology study with small group sizes and no hormone-intervention arm; the authors infer reduced GnRH/LH secretion rather than measuring treatment effects.

From the source

Evidence that undernutrition increases AgRP signaling to arcuate kisspeptin neurons in male and female lambs
The Journal of reproduction and development · 2026 Oct 17 · Boney SS, Renwick AN, Harlow KK et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42893863/