Half of GLP-1 starters report GI symptom events within five years, 78,000-patient study finds

The wire

1. 01In a retrospective cohort of 78,277 patients published in Neurogastroenterology and Motility, 53% reported at least one GI symptom event by 60 months, most often abdominal pain (28%) and nausea (25%).
2. 02Baseline diarrhea, constipation, abdominal pain or nausea raised risk (HRs 2.2, 2.0, 1.7, 1.6), as did concomitant metoclopramide (HR 1.6); women were at higher risk than men.
3. 03Prediction was modest (C-index 0.64 training, 0.63 testing), and the gastric emptying subgroup was only 696 symptom-selected referrals, so the 34.6% delayed-emptying rate is not generalizable.

From the source

Gastrointestinal Symptom Events and Motility Alterations Associated With GLP-1 Receptor Agonists

Neurogastroenterology and motility · 2026 Oct · Cisneros JZ, Lupianez-Merly C, Dilmaghani S et al.