Case report links oral semaglutide to recurrent ischemic colitis

The wire

1. 01Spanish clinicians report a 46-year-old woman on oral semaglutide for weight loss who had three episodes of abdominal pain and hematochezia; CT, rectosigmoidoscopy and histopathology confirmed ischemic colitis.
2. 02Authors say ischemic colitis should be considered as a rare adverse effect of GLP-1 receptor agonists when patients present with bloody diarrhea and abdominal pain.
3. 03This is a single case report; the authors call the association probable based on temporal relationship, withdrawal response and recurrence on rechallenge, not on controlled data.

From the source

Ischemic colitis associated with oral semaglutide with recurrence upon rechallenge

Revista espanola de enfermedades digestivas · 2026 Oct 8 · Aranda Rojas S, Chen Wang Y, Tavío Hernández E et al.