Researchsemaglutideoral-deliverysnacpermeation-enhancers

Lauroyl-L-carnitine outperforms SNAC for intestinal semaglutide absorption in rats

The enhancer boosted uptake through a dynamin-sensitive pathway and raised systemic exposure in beagle dogs and cynomolgus monkeys without overt tissue injury.

By Priya Raman · Science Reporter

Oct 18 20:00 ETSource: Journal of controlled release : official journal of the Controlled Release Society

The wire

01Researchers compared SNAC, N-dodecyl-beta-D-maltoside and lauroyl-L-carnitine for enteric semaglutide delivery; LLC gave the largest absorption increase in rats, an effect substantially attenuated by dynasore co-treatment.
02Oral semaglutide currently relies on SNAC for gastric absorption, so an enhancer suited to small-intestinal delivery could change how oral incretin formulations are built.
03DDM disrupted tight junctions with reduced barrier recoverability; the work is preclinical across Caco-2 monolayers, rats, dogs and monkeys, with no human dosing reported.

From the source

Mechanistic benchmarking of SNAC, DDM, and LLC reveals enhancer-dependent pathways for intestinal semaglutide delivery
Journal of controlled release : official journal of the Controlled Release Society · 2026 Oct 19 · Yuan B, Sui Y, Li H et al.

Read at pubmed.ncbi.nlm.nih.gov

Source URL https://pubmed.ncbi.nlm.nih.gov/42896658/